I agree that maintenance is very similar in terms of wear limits, cleaning the air filter, changing the oil, cleaning and adjusting the chain, etc....
For the average home mechanic, adjusting valves that use shims can be a bit beyond most. Not that it's impossible, just a little more challenging.
Where the two engines really differ is when something catastrophic happens. No matter what anyone my claim, two strokes will fail.
The big problem comes when a four-stroke has a major failure. There are just more parts, so in a logical way this makes sense.
The second part of that problem is that it at least appears that more four-stroke owners have experienced these catastrophic failures. And no they are not all linked to poor maintenance.
Maybe it's just because I know a lot of faster racers or something, but the highly modified bikes can blow even when all the proper maintenance is done and high wear parts are replaced on schedule.
On the other hand, if your four-stroke machine is stock and you don't run it against the rev limiter all the time (just watch Justin Barcia for an example of hitting the rev limiter) your bike could last literally for years.
Which points out that the rider and how he (or she) rides is a huge factor in the reliability of the four-strokes.