Back in the day, yes the early 70's (I know damn he's old) I ran at 30:1 on my 1974 Honda Elisinore CR125 ... and then in my 1974 Honda Elisinore CR250. Today, I use a full syn, and because I'm old school, I have changed the ratio to 42:1
Yes I too know of guys running at 100:1. Good for them, they have their opinion I have mine
I've jetted my bike (KTM 300) to fit the ratio I'm running... There's the key, jet the bike to the ratio you selected. In the past 10 years, I've fouled one plug. (I over oiled the air filter).
In other words, pick a ratio and brand of oil you can source locally (really they're all good), jet accordingly, and stick with it.